It's not so much the MOA's near Savannah as the restricted airspace at Fort Stewart. Stay east of all of them, maintain 2500 or more over Hunter Army Airfield, (and the antenna farm to the west of it) then stay west of the MOA's near Beaufort MCAS and you'll be fine, and headed in the right direction. In fact, a flight along the coastline from Florida is beautiful, and keeps you honest. Start to head direct to KLUX abeam 72GA and you should be in good shape.
..Joe